Advancing refinement of laboratory animal use
نویسندگان
چکیده
منابع مشابه
Refinement of experimental design and conduct in laboratory animal research.
The scientific literature of laboratory animal research is replete with papers reporting poor reproducibility of results as well as failure to translate results to clinical trials in humans. This may stem in part from poor experimental design and conduct of animal experiments. Despite widespread recognition of these problems and implementation of guidelines to attenuate them, a review of the li...
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متن کاملEstimates for worldwide laboratory animal use in 2005.
Animal experimentation continues to generate public and political concern worldwide. Relatively few countries collate and publish animal use statistics, yet this is a first and essential step toward public accountability and an informed debate, as well as being important for effective policy-making and regulation. The implementation of the Three Rs (replacement, reduction and refinement of anim...
متن کاملLaboratory Animal Science
| A spontaneous neurological mutation was detected in a colony of Sprague Dawley rats. The animals developed a progressive neurological syndrome characterized by tremor (which appeared at the age of 1 month), ataxia (at 4 months), immobility episodes (after 5-6 months), audiogenic seizures and hindlimb paralysis (after 10 months). Cross breeding experiments indicate that this is an autosomal re...
متن کاملLaboratory animal allergens.
Allergic sensitivity to laboratory animals can pose a significant occupational hazard to anyone with regular animal contact. Reactions to mice and rats are most common although all furred animals produce allergens that can lead to sensitization and disease. Most of the relevant allergens of laboratory animals have been defined and characterized, which has revealed that these allergens are typic...
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ژورنال
عنوان ژورنال: Laboratory Animals
سال: 1998
ISSN: 0023-6772,1758-1117
DOI: 10.1258/002367798780600016